The conflict, the most intense fighting between the two countries in decades, has been met in the United States with feelings of “frustration and helplessness,” as well as heartbreak.

The Israelis had the opportunity to assassinate Supreme Leader Ayatollah Ali Khamenei and President Trump conveyed to Prime Minister Benjamin Netanyahu that it wasn't a good idea, one U.S. official told CBS News.

Sen. Lindsey Graham told CBS's "Face The Nation" that he urges President Trump to be prepared to join Israel's attack on Iran up to and including "regime change," if a single American is targeted by Iran.

Countries trade strikes as tensions grow over larger Middle East conflict - Iranian missiles struck an apartment building in the Galilee region, killing four people, as the countries exchanged fire

The United States is the main international backer of Israel, Iran's biggest regional foe. It is also a close ally of Sunni Gulf monarchies which for years pursued their own rivalry with the Islamic Republic, seeing it as their main regional threat.

Iran launched multiple deadly waves of missiles and drones toward Israel into Saturday morning following Israel’s unprecedented strikes aimed at destroying Iran’s nuclear program and decapitating its military leadership.

Iranian officials said on Friday that the United States "shall be held fully accountable" for its support of Israel after the nation took out key Iranian nuclear facilities and killed government leaders in a series of air strikes this week.

National security experts warn that Israel's attack on Iran shows why Chinese land and asset purchases in the U.S. pose a significant threat to American security.