Speaking with her co-host Jamie-Lynn Sigler, who also has MS, on the latest episode of their MeSsy podcast, Applegate said, “I lay in bed screaming, like, the sharp pains, the ache, the squeezing.”

Christina Applegate has shared the grueling effects of her battle with Multiple Sclerosis. The “Dead To Me” actress, who was diagnosed with MS in early 2021, has been open about how the condition — which affects the brain and nerves — has affected her daily life and Hollywood career.

Christina Applegate has shared the horrific experiences she goes through living with multiple sclerosis (MS). The star was diagnosed with the condition following advice from fellow actor Selma Blair, who she confided in about strange symptoms she was experiencing.

Christina Applegate is opening up about what she deals with during her struggles with the condition multiple sclerosis.

The actress revealed that her symptoms have “traveled into my hands” as she continues to struggle with multiple sclerosis

The "Married... with Children" alum also revealed that the disease has "traveled into my hands" and makes it difficult to pick up objects.

She detailed the effect the autoimmune disease, “I can’t even pick up my phone sometimes…or get my remote…sometimes I can’t even hold them. I can’t open bottles now.”

"I can't even pick up my phone sometimes because now it's travelled into my hands, so I'll, like, try to go get my phone or get my remote to turn on the TV or sometimes, I can't even hold them. I can't open bottles now.

Christina Applegate share the reality of how hard it is living with multiple sclerosis (MS), including the severe pain. "I lay in bed screaming. Like, the sharp pains, the ache, the squeezing," said the Dead To Me actress during Tuesday's episode of her MeSsy podcast,