Donte DiVincenzo will not play Friday night when the Timberwolves visit Madison Square Garden for a matchup with Karl-Anthony Towns and the Knicks. His absence could pose significant challenges for Minnesota.

The 27-year-old guard has flirted with triple doubles in two of Minnesota’s last three outings. DiVincenzo tallied 28 points, nine assists, six rebounds, one steal and zero turnovers in the Wolves’ loss to the Warriors on Wednesday, making him the first player in franchise history to post such a line.

Putting DiVincenzo in the starting lineup also gives him a role closer to what he had in New York last season when he thrived as a spark-plug shooter and defender for the Knicks. He started 68 games in the regular season and every playoff game for New York.

Karl-Anthony Towns likely is the player the Knicks can least do without, especially with Mitchell Robinson still unable to practice.

FanDuel Sports Network, iHeart app Wolves update:G Donte DiVincenzo (left big toe sprain) will be sidelined after a strong game Wednesday in a home loss to Golden State. He had his second game of the season where he had 25+ points,

Donte DiVincenzo, a Knicks hero of last season’s playoffs, has been ruled out of Friday’s MSG return because of a sprained toe, the Timberwolves announced. It’ll represent the durable DiVincenzo’s first DNP of the season for the T’wolves and puts a damper on an anticipated matchup between offseason trade partners.