Trump warns Iran not to retaliate against U.S. targets in the Middle East while also predicting Israel and Iran would 'soon' make a deal to end their escalating conflict.

DUBAI, United Arab Emirates (AP) — Israel launched an expanded assault on Iran on Sunday, with direct strikes targeting its energy industry and Defense Ministry headquarters, while Tehran unleashed a fresh barrage of missiles blamed for the deaths of four people and injuries of many others.

The Israeli military struck "over 170 targets" in Iran in three days, the Israel Defense Forces (IDF) said on Sunday.

Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

Iran conflict could open opportunities for Russia to possibly become a power broker to help end the confrontation.

Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.

Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.