Ukraine struck Russian regions with a major drone and missile attack overnight, damaging at least two factories and forcing schools to close in a major southern Russian city, according to Russian officials and media.

Russia's military on Tuesday said it would retaliate against Ukraine after Kyiv attacked Russian regions by firing six U.S.-made ATACMS ballistic missiles, six UK-made Storm Shadow cruise missiles and launching one of the biggest drone attacks to date.

The barrage appeared to be one of the largest recent assaults in Ukraine’s campaign to damage Russia’s war machine on its home territory.